Your role

The PhD student will work on a project focusing on GBA1-associated Parkinson’s disease. The project aims to validate small-molecule compounds that rescue disease-associated cellular phenotypes in iPSC-derived neuronal models and midbrain organoids, with the goal of developing precision therapeutic approaches for genetically stratified PD subgroups.

Key Responsibilities:

• Generation of iPSCs from patient-donated fibroblasts
• Differentiate iPSCs into midbrain dopaminergic neurons and organoids for phenotyping and compound testing
• High content imaging and automated image-analysis
• Analyze omics data
• Collaborate closely with interdisciplinary teams of computational biologists, neuroscientists, and clinicians
• Prepare manuscripts, reports, and present findings at national and international conferences

Your profile

• Master’s degree in ...