The PhD project will combine organoid generation and long-term maintenance, MEA-based stimulation and recording, and closed-loop training protocols to probe how activity-dependent plasticity in the organoid reshapes functional connectivity during learning. The aim is both to advance OI as a computing paradigm and to use it as a window onto the cellular and network correlates of learning and memory in human neural tissue. The work is highly interdisciplinary, bridging wet-lab neurobiology, electrophysiology and computational analysis.
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