A*STAR - Agency for Science, Technology and Research
Location
singapore, Singapore
Type
Full-time
Key Responsibilities
Lead development and optimisation of GPCR functional assays, including reporter‑based systems (e.g., luciferase, cAMP, calcium, β‑arrestin readouts) suitable for medium‑ to high‑throughput screening.
Develop new reporter systems for additional functional or phenotypic endpoints beyond GPCR signalling.
Design, generate, and validate stable or transient mammalian reporter cell lines, including construct design, molecular cloning, and cell line engineering.
Collaborate with cross‑functional teams (e.g., chemistry, computational biology, screening teams) to support compound evaluation and mechanistic studies.
Analyse and interpret experimental data, including dose‑response relationships, assay performance metrics, and screening outputs.
Prepare scientific reports, presentations, and publications, and maintain rigorous documentation of experimental workflows.
Supervise and train junior sta...
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